Expansion of Betatorquevirus and/or Gammatorquevirus in Patients with Severe Clinical Outcomes of the Liver Diseases

Anellovirus (AV) is a ubiquitous virus in the human population. Individuals can be infected with multiple AV genera and species to form heterogeneous repertoire, termed anellome. Using advanced methods, we examined anellomes from 12 paired serum liver samples, as well 2701 subjects different clinical diagnoses. Overall, are remarkably individualized, significant among-group differences (Kruskal–Wallis test p = 6.6 × 10−162 for richness 7.48 Shannon entropy). High dissimilarity scores (beta diversity) were observed between patient groups, except samples. At population level, relative abundance of combinational genus Betatorquevirus (torque teno mini viruses, TTMV), Gammatorquevirus midi TTMDV) exhibited an exponential distribution low bound point at 32%. Defined by this value, TTMV/TTMDV-expanded anellome was significantly enriched among patients acute failure (31.7%) transplantation (40.7%), compared other groups (χ2 test: 4.1 10−8–3.2 10−3). Therefore, heterogeneity may predictive outcomes certain diseases, such disease. The consistency samples indicates that liquid biopsy approach would suitable longitudinal studies clarify causality